Issue 34, 2025

Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling

Abstract

Photocatalytic biomolecular labelling is gaining attention as a foundational technique for analyzing biological phenomena. However, photocatalytic reactions compatible with physiological conditions remain limited. Here, we present a photocatalytic reaction of diaryltetrazoles to generate nitrile imines, which readily couple with carboxylic acids in aqueous environments. This reaction is applied for photocatalyst-dependent labelling of proteins and cells.

Graphical abstract: Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling

Supplementary files

Article information

Article type
Communication
Submitted
06 Sep 2024
Accepted
21 Mar 2025
First published
24 Mar 2025
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2025,61, 6320-6323

Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling

T. Matsuoka, R. Takasaki, H. Akiba, K. Ogata, A. Hattori, N. Arichi, H. Kakeya, S. Yamasaki, Y. Ishihama, H. Ohno and S. Inuki, Chem. Commun., 2025, 61, 6320 DOI: 10.1039/D4CC04452E

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements