Using cationic fluorinated oxazolinium compounds, fluorescent cysteine-selective SNAr bioconjugation proceeds under mild conditions, resulting in fluorescent-labelled peptides and proteins with moderate to excellent conversions of up to 99%. Live cell imaging studies reveals good compatibility of these oxazoliniums as fluorescent dyes for mitochondrial targeting.
K. K. Kung, Y. T. Limanto, A. Tantipanjaporn, J. Deng, L. Y. Tsang and M. K. Wong, RSC Chem. Biol., 2025, Accepted Manuscript , DOI: 10.1039/D5CB00289C
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.
To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
