Advances of Laponite-Based Nanocarrier in Drug Delivery Applications

Abstract

Polymer nanocomposite delivery platform has drawn a surge in interest in recent years especially in the field of pharmaceutics. Here we present an overview of Laponite based nanoparticle drug delivery system (NDDS) along with Laponite physicochemical properties, drug encapsulation efficiency, and the factors influencing drug release, biodegradability, and stability. The underlying interaction and chemistry between Laponite, polymer and drug has been heavily covered. We present evidence of various triggering factors, such as pH, temperature, light, and magnetic fields, that facilitate the release of drugs from Laponite nanocarriers. Examples of the use of Laponite based nanocomposite in delivery of several types of therapeutics (anticancer, antibiotic, and anti-inflammatory), macromolecules and proteins have been highlighted as it relates to biomedical application. Several recommendations have been discussed including the potential to develop multifunctional, stimuli-responsive Laponite nanocarriers for smart and controlled delivery of drugs. Finally, we discuss future directions, emphasizing the potential of multifunctional, stimuli-responsive Laponite nanocarriers to enable smart, controlled drug delivery offering promising avenues for the treatment of chronic diseases.