Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

Kianna Nguyen; Quang Tuan Che; Quoc Huynh Nguyen; Kihak Gwon; Alan Gonzalez Suarez; Gulnaz Stybayeva; Robert Huebert; Quinn Peterson; Alexander Revzin

doi:10.1039/D5BM00696A

Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

Kianna Nguyen,

^a Quang Tuan Che,^b Quoc Huynh Nguyen,

^b Kihak Gwon,

^c Alan Gonzalez Suarez,

^b Gulnaz Stybayeva,

^b Robert Huebert,

^d Quinn Peterson

^b and Alexander Revzin

*^b

Author affiliations

* Corresponding authors

^a Medical Scientist Training Program, Mayo Clinic Alix School of Medicine & Mayo Clinic Graduate School of Biomedical Sciences, 200 1st St SW, Rochester, MN, USA
E-mail: nguyen.kianna@mayo.edu

^b Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN, USA
E-mail: che.quangtuan@mayo.edu, nguyen.huynh@mayo.edu, alan@sersense.com, stybayeva.gulnaz@mayo.edu, peterson.quinn@mayo.edu, revzin.alexander@mayo.edu

^c Department of Biofiber and Materials Science Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, South Korea
E-mail: khgwon@knu.ac.kr

^d Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st St SW, Rochester, MN, USA
E-mail: huebert.robert@mayo.edu

Abstract

Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

Article information

https://doi.org/10.1039/D5BM00696A

Article type

Review Article

Submitted

05 May 2025

Accepted

09 Jun 2025

First published

17 Jun 2025

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Biomater. Sci., 2025, Advance Article

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Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

K. Nguyen, Q. T. Che, Q. H. Nguyen, K. Gwon, A. Gonzalez Suarez, G. Stybayeva, R. Huebert, Q. Peterson and A. Revzin, Biomater. Sci., 2025, Advance Article , DOI: 10.1039/D5BM00696A

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Biomaterials Science

Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

Abstract

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Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions

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