Issue 11, 2025

Selenium-vacancy-mediated NiCoSe nanoplatforms with NIR-II amplified nanozymes for methicillin-resistant Staphylococcus aureus-infected pneumonia

Abstract

The clinical management of bacterial pneumonia (BP) induced by multidrug-resistant (MDR) pathogens poses substantial therapeutic challenges, necessitating urgent development of novel antibacterial agents and treatment paradigms, particularly those targeting deep-tissue biofilms. While reactive oxygen species (ROS)-mediated nanozyme-catalyzed therapy represents a promising therapeutic strategy, its effectiveness remains limited by the suboptimal nanozyme biocatalytic efficiency and restricted therapeutic efficacy of monomodal approaches. To address these challenges, we engineered selenium vacancy-enriched nickel–cobalt selenide (NiCoSe) nanoplatforms demonstrating dual functional capabilities: exceptional biocatalytic performance and superior photothermal conversion efficiency within the second near-infrared window (NIR-II). Systematic evaluations revealed that the NiCoSe platform facilitates robust ROS generation, achieving potent bactericidal effects while synergistically accelerating biofilm eradication through NIR-II photothermal activation. This combined therapeutic modality establishes NiCoSe as a promising candidate for anti-infective treatment of MDR-BP. Our findings not only present an innovative strategy for combating deep-seated bacterial infections but also advance the translational potential of nanozyme-based therapeutics in clinical nanomedicine.

Graphical abstract: Selenium-vacancy-mediated NiCoSe nanoplatforms with NIR-II amplified nanozymes for methicillin-resistant Staphylococcus aureus-infected pneumonia

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Article information

Article type
Paper
Submitted
07 Feb 2025
Accepted
21 Mar 2025
First published
25 Mar 2025

Biomater. Sci., 2025,13, 2994-3005

Selenium-vacancy-mediated NiCoSe nanoplatforms with NIR-II amplified nanozymes for methicillin-resistant Staphylococcus aureus-infected pneumonia

L. Wu, L. Jin, X. Zou, X. He, Y. Dai and J. Huang, Biomater. Sci., 2025, 13, 2994 DOI: 10.1039/D5BM00188A

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