Issue 4, 2025

Single-atom nanozymes with intelligent response to pathological microenvironments for bacterially infected wound healing

Abstract

Wound healing is a complex and dynamic process often accompanied by bacterial infection, inflammation, and excessive oxidative stress. Single-atom nanozymes with multi-enzymatic activities show significant potential for promoting the healing of infected wounds by modulating their antibacterial and anti-inflammatory properties in response to the wound's physiological environment. In this study, we synthesized MN4 single-atom nanozymes with multi-enzymatic activities that intelligently respond to pH value changes in the wound healing process. In vitro experiments confirm their effectiveness against Gram-negative bacteria, attributed to elevated reactive oxygen species (ROS) accumulation within the bacterial cells. Moreover, a full-thickness skin wound-infected model demonstrates that MN4 single-atom nanozymes accelerate wound repair and skin regeneration by suppressing the expression of tumor necrosis factor-alpha (TNF-α), promoting angiogenesis, and enhancing collagen deposition. In vivo biocompatibility experiments further demonstrate the favorable biocompatibility of these nanozymes, highlighting their potential for clinical applications in infected wound healing. These nanozymes respond intelligently to different microenvironments and may be suitable for addressing further complex and variable diseases.

Graphical abstract: Single-atom nanozymes with intelligent response to pathological microenvironments for bacterially infected wound healing

Supplementary files

Article information

Article type
Paper
Submitted
15 Oct 2024
Accepted
05 Dec 2024
First published
17 Jan 2025

Biomater. Sci., 2025,13, 1033-1044

Single-atom nanozymes with intelligent response to pathological microenvironments for bacterially infected wound healing

Z. Wan, Q. Liu, Y. Zhe, J. Li, D. Ding, S. Liu, H. Wang, H. Qiao, J. Yang, S. Zhang and X. Mu, Biomater. Sci., 2025, 13, 1033 DOI: 10.1039/D4BM01371A

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