Issue 29, 2025

Ultrasensitive detection of deoxynivalenol by mass spectrometric immunoassay with cascade signal amplification

Abstract

We developed a novel mass spectrometry immunoassay for the ultrasensitive and selective detection of deoxynivalenol by introducing nucleic-acid-amplification techniques. By selecting thymine as a mass tag, the primer DNA modified on the antibody could serve dual functions as both a signal probe and an initiator for the cascade amplification reaction.

Graphical abstract: Ultrasensitive detection of deoxynivalenol by mass spectrometric immunoassay with cascade signal amplification

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Article information

Article type
Communication
Submitted
30 Apr 2025
Accepted
09 Jun 2025
First published
23 Jun 2025

Anal. Methods, 2025,17, 5993-5996

Ultrasensitive detection of deoxynivalenol by mass spectrometric immunoassay with cascade signal amplification

H. Ji, J. Xu, Y. Li, X. Wu, D. Jiang, X. Mei, M. Yang, Y. Qiang, J. Zhou and C. Zhang, Anal. Methods, 2025, 17, 5993 DOI: 10.1039/D5AY00724K

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