This study demonstrated a liposome-targeted and accelerated CRISPR strategy for specific response of miR-21 within MCF-7 cells. Targeting was achieved with the help of modification of the MUC1 aptamer. MnO2 NS could be used as both a delivery vehicle and an accelerator for the CRISPR system, and finally to achieve spatially selective imaging of miR-21.
W. Zhang, M. Wu, Q. Zhang, X. Chen and Y. Guo, Anal. Methods, 2025, Accepted Manuscript , DOI: 10.1039/D5AY00619H
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