Issue 14, 2025

An indolizine-derived chemodosimeter with enhanced emission in a micellar environment for ppb-level detection of mercury ions

Abstract

Mercury is a harmful heavy metal that gravely threatens the environment and organisms. In the current study, 2-(1,3-oxathiolan-2-yl)-1,3-diphenylindolizine (DPIC-OS) and 2-(1,3-dithiolan-2-yl)-1,3-diphenylindolizine (DPIC-SS) probes are designed by protecting a 1,3-diphenylindolizine-2-carbaldehyde (DPIC-CHO) with mercury-recognizable 1,3-dithiolane and 1,3-oxathiolane moieties and utilized for the selective detection of Hg2+ ions in a micellar medium. Hydrophobic probes DPIC-OS and DPIC-SS exhibit intense fluorescence in the confined environment of a micellar solution. A significant enhancement in fluorescence intensity was seen for these probes upon switching from organic to aqueous micellar media. Upon the incremental addition of Hg2+ ions, the probes display a fluorescence shift, exhibiting a bluish-green emission at 505 nm through the release of fluorescent DPIC-CHO in the working solution by the spontaneous cleavage of the thioacetal linkage. DPIC-OS was more efficient than DPIC-SS, and subsequent analytical studies were conducted with this probe. The DPIC-OS exhibited no or insignificant response towards numerous common anions, cations, and small molecules, affirming its selectivity to Hg2+ ions and offering a low limit of detection (LOD) of 3.2 ppb (16.2 nM). The real-sample analysis by spiking mercury ions in water showed excellent percentage recoveries.

Graphical abstract: An indolizine-derived chemodosimeter with enhanced emission in a micellar environment for ppb-level detection of mercury ions

Supplementary files

Article information

Article type
Paper
Submitted
06 May 2025
Accepted
04 Jun 2025
First published
04 Jun 2025
This article is Open Access
Creative Commons BY-NC license

Analyst, 2025,150, 3208-3216

An indolizine-derived chemodosimeter with enhanced emission in a micellar environment for ppb-level detection of mercury ions

A. A. Pinheiro, A. Thakuri, S. Saha, M. Banerjee and A. Chatterjee, Analyst, 2025, 150, 3208 DOI: 10.1039/D5AN00502G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements