Spectroscopic chiral discrimination of naproxen isomers with cellulose tris(3,5-dimethylphenylcarbamate)-modified mesoporous hollow polymer microspheres

Abstract

Mesoporous hollow polymer microspheres (M-HPMs) are modified with cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC), and the obtained chiral hollow polymer microspheres (C-HPMs) are utilized for the spectroscopic chiral discrimination of naproxen (NPX) isomers. Thanks to the intrinsic chirality of CDMPC and the mesoporous structure of M-HPMs, the NPX isomers exhibit significant differences in their absorbances in the ultraviolet (UV) spectra after being adsorbed by the C-HPMs. Several parameters, including adsorption time, mass ratio of CDMPC to M-HPMs, and NPX concentration, are optimized to achieve the highest discrimination efficiency for the NPX isomers. Compared with the M-HPMs modified with sodium carboxymethyl cellulose and the hollow polymer microspheres (HPMs) directly modified with CDMPC, the C-HPMs show higher discrimination efficiency for the NPX isomers.