Flow solitons of supermolecular complex by DEAE-Dextran-MMA Copolymer/Small noncoding RNAs for epigenetic change fromcancer to normal cells in TME

Abstract

The DDMC (DEAE-Dextran-MMA copolymer)/sncRNAs (a-miR-155, piR-30074, and miR-125b) complex showed complete cure of mice with virus-induced sarcoma after cellular reprogramming treatment by transforming cancer cells into normal cells. With the kinetics of tumor growth inhibition, the difference from the control ¹mm2º of one intravenous injection and two intravenous injections is the same curvature and speed, so it is a soliton wave with a permanent shape (speed, shape) such that a faster soliton overcomes another without any change in shape in the case of two intravenous injections. The signal transduction for this drug delivery system (DDS) should be Hill Sigmoid type following the nonlinear Schrodinger model by energy transfer, the sine-Gordon soliton model by pulse and the Fisher-Kolmogorov soliton model by mass transfer. We found that the cellular output/entry response of DDMCs/sncRNAs is more dependent on the soliton signal which does not lose energy and shape without blocking the communication. The soliton-induced endoplasmic reticulo-mitochondrial Ca2+ fluxes to the chromosome in the nucleus will take place epigenetic modifications on the 5-position of cytosine (5mC) by Tet enzymes and thymine DNA glycosylase (TDG) as a global intracellular reaction. By soliton flux, the result shows that the quantummechanical equations can be related to epigenetic control with Ca2+ fluxes followed by theʠ induced fit model ʡ Hill equation.