Differentiation of cisplatin uptake within a population of cancer cells – how to “crack this nut” using single-cell ICP-MS

Zuzanna Szymańska; Magdalena Matczuk; Agnieszka Żuchowska; Paweł Romańczuk; Andrei R. Timerbaev; Maciej Jarosz

doi:10.1039/D5AN00152H

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Differentiation of cisplatin uptake within a population of cancer cells – how to “crack this nut” using single-cell ICP-MS

Zuzanna Szymańska,^a Magdalena Matczuk,

*^a Agnieszka Żuchowska,^b Paweł Romańczuk,^b Andrei R. Timerbaev

^c and Maciej Jarosz^a

Author affiliations

* Corresponding authors

^a Chair of Analytical Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, Poland
E-mail: magdalena.matczuk@pw.edu.pl

^b Chair of Medical Biotechnology, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, Poland

^c Institute of Inorganic Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria

Abstract

A versatile tool to unravel the uptake diversity of a front-line anticancer drug, cisplatin, within a cancer cell population is proposed herein based on single-cell inductively coupled plasma mass spectrometry. The interested researcher is provided with a tutorial to help adapt such cutting-edge methodology and know-how to reliable data processing.

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DOI: https://doi.org/10.1039/D5AN00152H
Article type: Communication
Submitted: 10 Feb 2025
Accepted: 26 Aug 2025
First published: 02 Sep 2025
This article is Open Access

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Analyst, 2025,150, 5374-5378

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Differentiation of cisplatin uptake within a population of cancer cells – how to “crack this nut” using single-cell ICP-MS

Z. Szymańska, M. Matczuk, A. Żuchowska, P. Romańczuk, A. R. Timerbaev and M. Jarosz, Analyst, 2025, 150, 5374 DOI: 10.1039/D5AN00152H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Differentiation of cisplatin uptake within a population of cancer cells – how to “crack this nut” using single-cell ICP-MS

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Differentiation of cisplatin uptake within a population of cancer cells – how to “crack this nut” using single-cell ICP-MS

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