We reported a novel DNA lesion-modified nanotweezer that underwent conformational switch upon ALKBH enzymes-mediated lesion repair. We demonstrated that the DNA lesion-modified nanotweezer enabled specifically and rapidly monitoring ALKBH2 and ALKBH3 activities and screening inhibitors. Important, this strategy allowed evaluating ALKBH2-associated drug resistance in cells.
F. Jiang, C. Zhang, X. Wang, Y. Yin, J. Hong, H. Tang, L. Tang and Z. Wu, Analyst, 2025, Accepted Manuscript , DOI: 10.1039/D5AN00099H
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
