Issue 27, 2024

Assembled collagen films modified using polyacrylic acid with improved mechanical properties via mineralization

Abstract

The imperative task of enforcing collagen materials holds paramount significance in the field of hard tissue repair. We hereby present mineralized collagen fiber films via mineralization with improved mechanical properties. Self-extracted collagen was assembled into an array with an aligned fibrous pattern and then modified with polyacrylic acid (PAA) followed by mineralization in cationic polyacrylamide (CPAM)–SBF. Biomineralization occurred at the inner and outer surface of the assembled collagen fiber films. A tensile strength of up to 40.38 ± 3.08 MPa of mineralized collagen was obtained, for the first time, which may be attributed to the synergistic effect of polyanion and polycation on the mineralization process of assembled intrafibrillar collagen fibers. It was argued that PAA may facilitate the intra-fiber interaction of collagen, which extends the elongation at break of collagen fibers. This study introduces a pioneering approach for the preparation of mineralized collagen materials with superior mechanical properties, which would be beneficial for hard tissue repair.

Graphical abstract: Assembled collagen films modified using polyacrylic acid with improved mechanical properties via mineralization

Supplementary files

Article information

Article type
Paper
Submitted
16 Apr 2024
Accepted
30 May 2024
First published
14 Jun 2024

J. Mater. Chem. B, 2024,12, 6643-6653

Assembled collagen films modified using polyacrylic acid with improved mechanical properties via mineralization

X. Chen, Z. Huang, S. Zhang and H. Li, J. Mater. Chem. B, 2024, 12, 6643 DOI: 10.1039/D4TB00828F

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