Issue 18, 2024

Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties

Abstract

A robust and easily manufactured high-strength and long-term release hydrazone-based isoniazid acrylic (HIA) bone cement is reported. The mechanical strength of HIA bone cement is similar to that of normal polymethyl methacrylate (PMMA) bone cement, far surpassing that of traditional isoniazid-containing antibiotic-loaded bone cement (INH bone cement). Isoniazid is connected to the bone cement through bioorthogonal hydrazone chemistry, and it possesses release properties superior to those of INH bone cement, allowing for the sustained release of isoniazid for up to 12 weeks. In vivo and in vitro studies also indicate that HIA cement exhibits better biocompatibility than INH bone cement. The results of this study not only signify progress in the realm of antimicrobial bone cement for addressing bone tuberculosis but also enhance our capacity to create and comprehend high-performing antimicrobial bone cement.

Graphical abstract: Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties

Supplementary files

Article information

Article type
Paper
Submitted
09 Nov 2023
Accepted
02 Apr 2024
First published
04 Apr 2024

J. Mater. Chem. B, 2024,12, 4389-4397

Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties

Y. Xu, H. Lin, Z. Gao, R. Guo, Y. Kan, L. Han, W. Bu, Z. Wang, A. Asilebieke, L. Han, C. Li, F. He and J. Chu, J. Mater. Chem. B, 2024, 12, 4389 DOI: 10.1039/D3TB02661B

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