Issue 32, 2024

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Abstract

The regulation of cellular behavior within a three-dimensional (3D) environment to execute a specific function remains a challenge in the field of tissue engineering. In native tissues, cells and matrices are arranged into 3D modular units, comprising biochemical and biophysical signals that orchestrate specific cellular activities. Modular tissue engineering aims to emulate this natural complexity through the utilization of functional building blocks with unique stimulation features. By adopting a modular approach and using well-designed biomaterials, cellular microenvironments can be effectively decoupled from their macro-scale surroundings, enabling the development of engineered tissues with enhanced multifunctionality and heterogeneity. We overview recent advancements in decoupling the cellular micro-scale niches from their macroenvironment and evaluate the implications of this strategy on cellular and tissue functionality.

Graphical abstract: Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

Article information

Article type
Review Article
Submitted
03 Mar 2024
Accepted
17 Jul 2024
First published
25 Jul 2024

Soft Matter, 2024,20, 6313-6326

Strategies to decouple cell micro-scale and macro-scale environments for designing multifunctional biomimetic tissues

M. Ghasemzadeh-Hasankolaei, D. Pinheiro, S. Nadine and J. F. Mano, Soft Matter, 2024, 20, 6313 DOI: 10.1039/D4SM00276H

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