Volume 3, 2024

Paper integrated microfluidic contact lens for colorimetric glucose detection

Abstract

Contact lenses offer a simple, cost-effective, and non-invasive method for in situ real-time analysis of various biomarkers. Electro-chemical sensors are integrated into contact lenses for analysis of various biomarkers. However, they suffer from rigid electronic components and connections, leading to eye irritation and biomarker concentration deviation. Here, a flexible and microfluidic integrated paper-based contact lens for colorimetric analysis of glucose was implemented. Facilitating a three-dimensional (3D) printer for lens fabrication eliminates cumbersome cleanroom processes and provides a simple, batch compatible process. Due to the capillary force of the filter paper, the sample was routed to detection chambers inside microchannels, and it allowed further colorimetric detection. The paper-embedded microfluidic contact lens successfully detects glucose down to 2 mM within ∼10 s. The small dimension of the microfluidic system enables detection of glucose levels as low as 5 μl. The results show the potential of the presented approach to analyze glucose concentration in a rapid manner. It is demonstrated that the fabricated contact lens can successfully detect glucose levels of diabetic patients.

Graphical abstract: Paper integrated microfluidic contact lens for colorimetric glucose detection

Supplementary files

Article information

Article type
Paper
Submitted
29 Apr 2024
Accepted
18 Jul 2024
First published
05 Aug 2024
This article is Open Access
Creative Commons BY-NC license

Sens. Diagn., 2024,3, 1743-1748

Paper integrated microfluidic contact lens for colorimetric glucose detection

P. K. Isgor, T. Abbasiasl, R. Das, E. Istif, U. C. Yener and L. Beker, Sens. Diagn., 2024, 3, 1743 DOI: 10.1039/D4SD00135D

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