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In view of the worldwide impact of SARS-CoV-2, developing rapid and accurate ELISA-based methods for detecting SARS-CoV-2 is of great importance for diagnosing and controlling coronavirus disease 2019. Herein, we report highly stable and fluorescently bright Si–rhodamine analogues with obviously improved Stokes shifts for IgG antibody labelling. These new fluorescent dye labels provide a promising fluorescence tool for SARS-Cov-2 detection.

Graphical abstract: Si–rhodamine derivative with a large stokes shift for ELISA-based detection of SARS-CoV-2

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