Volume 3, 2024

A fluorescent sp2c-covalent organic polymer with an aggregation-induced emission unit to suppress aggregation-induced quenching for sensing furazolidone

Abstract

Furazolidone (FZD) is a nitrofuran antibiotic that has an inhibitory effect on a variety of Gram-negative and positive bacteria. However, excessive use of FZD can produce major adverse responses and irreversible harm to the central nervous system, so it is necessary to develop a simple, rapid, highly selective and sensitive method for the detection of FZD. Here, a sp2c-covalent organic polymer (COPPDAN-BTT) containing benzotrithiophene was synthesized for fluorescence sensing FZD. The benzotrithiophene in the BTT monomer is a typical aggregation-induced quenching (ACQ) fluorophore, and the cyanide diphenylethylene unit has certain aggregation-induced emission (AIE) properties. The connection of the ACQ fluorophore and the AIE fluorophore can fully improve the ACQ degree of COPPDAN-BTT. Under excitation at 370 nm, COPPDAN-BTT exhibits green fluorescence at 500 nm. Based on the internal filtering effect, COPPDAN-BTT was used for FZD detection. The I0/I showed a good linear relationship with the concentration of FZD in the range of 0.034–20 μg mL−1 (0.149–88.9 μM), and the detection limit was as low as 0.011 μg mL−1 (0.049 μM). Based on the AIE properties of COPPDAN-BTT, a fluorescent test strip was prepared for visual detection of FZD. This work provides a simple yet effective method for detection of FZD and improving the fluorescence of COPs.

Graphical abstract: A fluorescent sp2c-covalent organic polymer with an aggregation-induced emission unit to suppress aggregation-induced quenching for sensing furazolidone

Supplementary files

Article information

Article type
Paper
Submitted
18 Nov 2023
Accepted
24 Jan 2024
First published
29 Jan 2024
This article is Open Access
Creative Commons BY-NC license

Sens. Diagn., 2024,3, 448-454

A fluorescent sp2c-covalent organic polymer with an aggregation-induced emission unit to suppress aggregation-induced quenching for sensing furazolidone

X. Wang, L. Kuang, M. Ye, L. Zou, L. Wang and Y. Song, Sens. Diagn., 2024, 3, 448 DOI: 10.1039/D3SD00307H

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