Copper-oxygen adducts: new trends in characterization and properties towards C−H activation

Abstract

This review summarizes the latest discoveries in the field of C−H activation by copper monoxygenases and more particularly by their bioinspired systems. This work first describes recent background on copper-containing enzymes along with additional interpretations about the nature of the active copper-oxygen intermediates. It then focuses on relevant examples of bioinorganic synthetic copper-oxygen intermediates according to their nuclearity (mono to polynuclear). This includes a detailed description of the spectroscopic features of these adducts as well as their reactivity towards the oxidation of recalcitrant C_sp³-H bonds. The last part is devoted to the significant expansion of heterogeneous catalytic systems based on copper-oxygen cores (i.e. within zeolites frameworks).