Issue 3, 2024

Electrochemical assembly of isoxazoles via a four-component domino reaction

Abstract

Multicomponent domino reactions via electrochemical annulations have emerged as a robust strategy for the rapid assembly of heterocyclics. Herein, an electrochemical annulation via a [1 + 2 + 1 + 1] four-component domino reaction was accomplished in a user-friendly undivided cell setup to assemble valuable five-membered isoxazole motifs. Our approach is characterized by a high level functional group tolerance and operational simplicity, avoiding the tedious and time-consuming preparation of pre-functionalized substrates. Detailed mechanistic studies were conducted including isotopic labeling, kinetic studies, cyclic voltammetry (CV) analysis, and intermediate characterization, providing support for a radical pathway.

Graphical abstract: Electrochemical assembly of isoxazoles via a four-component domino reaction

Supplementary files

Article information

Article type
Edge Article
Submitted
06 Nov 2023
Accepted
10 Dec 2023
First published
11 Dec 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2024,15, 1117-1122

Electrochemical assembly of isoxazoles via a four-component domino reaction

Y. Zhao, X. Li, S. L. Homölle, B. Wang and L. Ackermann, Chem. Sci., 2024, 15, 1117 DOI: 10.1039/D3SC05946D

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