Issue 3, 2024

Automated multistep synthesis of 2-pyrazolines in continuous flow

Abstract

The rapid multistep synthesis of 2-pyrazolines from aldehydes via [3 + 2] cycloaddition of unstabilised diazo species and mono and di-substituted alkenes is reported. The development encompasses semi-continuous and fully continuous methods, including a fully automated compound library generation. A graphical interface was developed for the automation control, making it more accessible for chemists without coding experience.

Graphical abstract: Automated multistep synthesis of 2-pyrazolines in continuous flow

Supplementary files

Article information

Article type
Paper
Submitted
01 Oct 2023
Accepted
06 Nov 2023
First published
09 Nov 2023
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2024,9, 558-565

Automated multistep synthesis of 2-pyrazolines in continuous flow

R. Labes, J. C. Pastre, R. J. Ingham, C. Battilocchio, H. M. Marçon, M. C. F. C. B. Damião, D. N. Tran and S. V. Ley, React. Chem. Eng., 2024, 9, 558 DOI: 10.1039/D3RE00515A

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