Issue 41, 2024, Issue in Progress
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RSC Advances

Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles†

Yalin Qi, ORCID logo ‡ab   Hesong Han, ORCID logo ‡ab   Albert Liu,ab   Sheng Zhao,ab   Atip Lawanprasert,ab   Josefine Eilsø Nielsen,cd   Hema Choudhary,ab   Dengpan Liang,ab   Annelise E. Barron ORCID logo c  and  Niren Murthy ORCID logo *ab  

* Corresponding authors

a Department of Bioengineering, University of California, Berkeley, Berkeley, California 94720, USA
E-mail: nmurthy@berkeley.edu

b Innovative Genomics Institute (IGI), Berkeley, California 94704, USA

c Department of Bioengineering, School of Medicine, Stanford University, Stanford, California 94305, USA

d Department of Science and Environment, Roskilde University, Roskilde 4000, Denmark

Abstract

Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

Graphical abstract: Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

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Article information

DOI
https://doi.org/10.1039/D4RA05007J
Article type
Paper
Submitted
11 Jul 2024
Accepted
10 Sep 2024
First published
20 Sep 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 30071-30076

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Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

Y. Qi, H. Han, A. Liu, S. Zhao, A. Lawanprasert, J. E. Nielsen, H. Choudhary, D. Liang, A. E. Barron and N. Murthy, RSC Adv., 2024, 14, 30071 DOI: 10.1039/D4RA05007J

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