Issue 21, 2024

Developments and applications of α-bromonitrostyrenes in organic syntheses

Abstract

The presence of the bromo and nitro groups in the structure of α-bromonitrostyrene makes them highly reactive and versatile reagents in organic syntheses. α-Bromonitrostyrenes act as an effective dielectrophile in the reaction with various nucleophiles. In these reactions, the bromo and nitro groups behave as good leaving groups for the assembly of a diverse range of heterocyclic compounds, such as dihydrofurans, dihydropyranes, furans, pyrroles, pyrazoles, isooxazolines, spiropyrrolidines, etc. In the current review, we have focused on the transformations of α-bromonitrostyrenes under organocatalysis, metal catalysis, and base-catalysis systems as well as catalyst-free conditions, since 2010.

Graphical abstract: Developments and applications of α-bromonitrostyrenes in organic syntheses

Article information

Article type
Review Article
Submitted
01 Apr 2024
Accepted
29 Apr 2024
First published
08 May 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 14835-14846

Developments and applications of α-bromonitrostyrenes in organic syntheses

F. Doraghi, M. M. Aghanour Ashtiani, F. Moradkhani, B. Larijani and M. Mahdavi, RSC Adv., 2024, 14, 14835 DOI: 10.1039/D4RA02474E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements