Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers

Claus Bøge Hansen; Anna Janaszewska; Monika Dąbrzalska; Monika Marcinkowska; Barbara Klajnert-Maculewicz; Jørn Bolstad Christensen

doi:10.1039/D4RA02020K

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Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers†

Claus Bøge Hansen,^a Anna Janaszewska,

^b Monika Dąbrzalska,

^b Monika Marcinkowska,^b Barbara Klajnert-Maculewicz

^b and Jørn Bolstad Christensen

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark
E-mail: jbc@chem.ku.dk

^b Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland

Abstract

A series of 6 small PAMAM dendrimers (G0-dendrimers) differing in the size, polarity and flexibility has been synthesized. The toxicity has been investigated in three different human cancer cell lines (HeLa, MCF-7, THP-1) and the endothelial skin cell line HMEC-1 in order to evaluate their potential as vehicles for drug delivery.

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DOI: https://doi.org/10.1039/D4RA02020K
Article type: Paper
Submitted: 16 Mar 2024
Accepted: 30 Aug 2024
First published: 10 Sep 2024
This article is Open Access

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RSC Adv., 2024,14, 28684-28692

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Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers

C. B. Hansen, A. Janaszewska, M. Dąbrzalska, M. Marcinkowska, B. Klajnert-Maculewicz and J. B. Christensen, RSC Adv., 2024, 14, 28684 DOI: 10.1039/D4RA02020K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers†

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Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers

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