Issue 5, 2024, Issue in Progress

Synthesis of 2-amino-9H-chromeno[2,3-d]thiazol-9-ones with anti-inflammatory activity via cascade reactions of 2-amino-3 iodochromones with amines and carbon disulfide

Abstract

A simple and efficient synthetic approach to 2-amino-9H-chromeno[2,3-d]thiazol-9-ones via copper-promoted cascade reactions was developed. The reaction employed easily available 2-amino-3-iodochromones and amines as substrates and the targeting tricyclic compounds could be obtained with moderate to good yields. Even more important, several synthesized compounds exhibited potent anti-inflammatory activities, which suggested that this protocol may provide valuable hits for drug development in the future.

Graphical abstract: Synthesis of 2-amino-9H-chromeno[2,3-d]thiazol-9-ones with anti-inflammatory activity via cascade reactions of 2-amino-3 iodochromones with amines and carbon disulfide

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Article information

Article type
Paper
Submitted
23 Oct 2023
Accepted
09 Jan 2024
First published
19 Jan 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 3158-3162

Synthesis of 2-amino-9H-chromeno[2,3-d]thiazol-9-ones with anti-inflammatory activity via cascade reactions of 2-amino-3 iodochromones with amines and carbon disulfide

J. Tan, Y. He, Y. Lin, Y. Zhong, S. He, J. Zuo and C. Yang, RSC Adv., 2024, 14, 3158 DOI: 10.1039/D3RA07209F

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