Non-Kolbe oxidation driven electrochemical C(sp2)–H lactonization towards the synthesis of isocoumarins

Abstract

A novel method for electrochemical C(sp²)–H lactonization was developed. This strategy enabled the synthesis of various isocoumarins in moderate to excellent yields with good functional group tolerance. The gram-scale reaction and derivatizations of the product showed the applicability of this method. Relevant mechanism experiments supported the rare non-Kolbe process. Overall, this work provides a sustainable and cheaper approach for the synthesis of isocoumarins.