Organo-initiator enabled undirected C–H amination of arenes

Abstract

The demand for transition-metal-free protocols in the C–H amination of aromatic compounds is significant but remains elusive. In this study, we explore the use of a picolinic acid-derived organo-initiator to facilitate undirected C–H amination of simple arenes. An investigation of substitutional effects provides valuable insights into the electronic and steric influences on C–H amination reactivity. Our protocol exhibits broad applicability in the C–H amination of various simple arenes and bioactive compounds.