A general photochemical strategy for the oximation of activated alkenes without a catalyst

Abstract

Oximes are crucial in several areas such as synthetic chemistry, medicinal chemistry, and materials science. In this context, we have developed a general photochemical approach for synthesizing diverse oximes without catalysts. Our protocol demonstrated broad applicability in various alkene oximation reactions, such as phosphoryloximation, sulfonyloximation, and trifluoromethyl-oximation. Furthermore, this protocol could be extended to obtain alkenyl and alkynyl phosphine oxides. Characterized by its mild conditions, broad substrate compatibility, straightforward operation, and scalability, our synthetic strategy stands out. The simple and modular method offers a new perspective for chemists to rapidly obtain various radical intermediates in an environmentally friendly and sustainable way.