Issue 13, 2024

Base-promoted fused β-carboline formation from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts

Abstract

A novel base-promoted fused β-carboline formation strategy from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts has been developed. In this cascade reaction, ammonium salts served as a convenient nitrogen source and simultaneously played an important role in selectivity control, which can efficiently afford two different types of β-carbolines in satisfactory yields.

Graphical abstract: Base-promoted fused β-carboline formation from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts

Supplementary files

Article information

Article type
Research Article
Submitted
26 Mar 2024
Accepted
03 May 2024
First published
08 May 2024

Org. Chem. Front., 2024,11, 3583-3588

Base-promoted fused β-carboline formation from 2-(1H-indol-3-yl)cyclohexan-1-ones, aldehydes and ammonium salts

J. Chen, Y. Zhang, X. Liu, K. Liu, J. Wu, X. Peng and G. Deng, Org. Chem. Front., 2024, 11, 3583 DOI: 10.1039/D4QO00551A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements