Synthesis of heteroaryl C-glycosides via Ru-catalyzed C–H activation/cyclization: dioxazolone glycogen designs and applications

Abstract

New glycogen reagents of dioxazolone glycogen anomers have been developed. The versatile heteroarene C-glycosides have been synthesized using a Ru-catalyzed C–H activation/annulation strategy, employing these dioxazolone glycogen anomers. These reactions tolerate various saccharide donors and enable stereoselective synthesis of heterocyclic C-glycosides. The strategy and methods were well applicable to a large-scale reaction and late-stage modification of structurally complex natural products.