Issue 14, 2024

Synthesis of (E)-vinyl sulfides via copper-catalyzed hydrothiolation of internal alkynes with thiosulfonates and silanes

Abstract

A copper-catalyzed syn-hydrothiolation of internal alkynes with thiosulfonates and silanes has been disclosed, which offers regio- and stereoselective access to (E)-vinyl sulfides. This highly selective process, which can be performed on a gram-scale, features operational simplicity and conditions not involving the use of smelly thiols.

Graphical abstract: Synthesis of (E)-vinyl sulfides via copper-catalyzed hydrothiolation of internal alkynes with thiosulfonates and silanes

Supplementary files

Article information

Article type
Research Article
Submitted
12 Mar 2024
Accepted
25 May 2024
First published
29 May 2024

Org. Chem. Front., 2024,11, 3982-3987

Synthesis of (E)-vinyl sulfides via copper-catalyzed hydrothiolation of internal alkynes with thiosulfonates and silanes

M. Gao, J. Li, L. Chen, Z. Qin, W. Wang, W. Dong, M. Liu, X. Zhang and C. Tao, Org. Chem. Front., 2024, 11, 3982 DOI: 10.1039/D4QO00448E

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