Diastereoselective synthesis of cis-cyclopentane-1,2-diamine derivatives via organophotoredox-catalyzed [3 + 2] cycloadditions

Abstract

A highly diastereoselective organophotoredox-catalyzed [3 + 2] cycloaddition of N-aryl cyclopropylamines with N-vinylphthalimides was reported. This transformation leads to diverse cis-cyclopentane-1,2-diamine derivatives via a dual catalyst system Eosin Y and Binol-derived phosphoric acid with Et₃N as an additive.