Issue 11, 2024

Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones

Abstract

A simple and general approach for the synthesis of ketones via a metal-free denitrogenative alkylation of vinyl azides with redox-active esters or Katritzky salts under visible light irradiation is described herein. This method features a broad substrate scope and good functional group compatibility including valuable transformation of bioactive molecules, thereby providing a sustainable and alternative technique for ketone preparation compared to the present strategies.

Graphical abstract: Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones

Supplementary files

Article information

Article type
Research Article
Submitted
09 Feb 2024
Accepted
11 Apr 2024
First published
12 Apr 2024

Org. Chem. Front., 2024,11, 3124-3130

Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones

H. Yin, S. Jian, X. Feng, M. Bao and X. Zhang, Org. Chem. Front., 2024, 11, 3124 DOI: 10.1039/D4QO00280F

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