Issue 12, 2024

Archimedean heterologous helixes in Ti10Cd6-oxo nanoclusters: double-helical self-assembly and therapeutic application in Parkinson's disease

Abstract

The construction of spiral nanostructures has been a long and challenging pursuit. Herein, we report a helical cadmium doping titanium-oxo cluster (Ti10Cd6), which can be extracted from Archimedean spiral curves using the equation r = 1 + 1.5θ (θ = 0–350°). A heterologous helix as the building block is further assembled into a double-stranded helical superstructure through intra- and inter-strand non-covalent interactions. Furthermore, the enantioseparation of the novel helix was realized through chiral ligand exchange. Moreover, biological application of the enantiomer R-/S-Ti10Cd6 was studied, and the results show that R-Ti10Cd6 significantly ameliorates the degeneration of dopaminergic neurons compared to S-Ti10Cd6 in a C. elegans model of Parkinson's disease, suggesting an important role of chirality in biomedical applications of metal-oxo clusters.

Graphical abstract: Archimedean heterologous helixes in Ti10Cd6-oxo nanoclusters: double-helical self-assembly and therapeutic application in Parkinson's disease

Supplementary files

Article information

Article type
Research Article
Submitted
08 Apr 2024
Accepted
29 Apr 2024
First published
03 May 2024

Inorg. Chem. Front., 2024,11, 3527-3537

Archimedean heterologous helixes in Ti10Cd6-oxo nanoclusters: double-helical self-assembly and therapeutic application in Parkinson's disease

L. Meng, J. Chen, Z. Feng, Z. Jiang, Z. Jin and C. Zhan, Inorg. Chem. Front., 2024, 11, 3527 DOI: 10.1039/D4QI00890A

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