Chiral iodine-catalyzed asymmetric oxyamination of unactivated olefins

Abstract

In this paper, chiral aryl iodides were used for the first time to catalyze the formation of C–O and C–N bonds of inactive olefins to obtain optically active aminolactone derivatives. The reaction is compatible with various substituted alkenyl carboxylic acid substrates. This method usually shows high activity and enantioselectivity, with a yield of up to 83% and an ee of up to 99%. It is recovery and reuse of chiral aryl iodide catalyst CIC4 showed almost no loss in product yield and enantioselectivity after 3 runs.