Issue 47, 2024

Radical alkylation of acrylamides with peroxides to access mono/dialkylated fused N-heterocycles

Abstract

A simple mono/dialkylation of acrylamide derivatives was achieved, affording diverse mono/dialkylated benzo[4,5]imidazo[2,1-a]isoquinolines or polycyclic coumarins with good substrate scope. This system used common peroxides as alkylating reagents. Meanwhile, a series of scaled-up reactions and mechanistic explorations well demonstrated the application and reaction process of this cascade system.

Graphical abstract: Radical alkylation of acrylamides with peroxides to access mono/dialkylated fused N-heterocycles

Supplementary files

Article information

Article type
Communication
Submitted
24 Sep 2024
Accepted
16 Oct 2024
First published
17 Oct 2024

Org. Biomol. Chem., 2024,22, 9184-9187

Radical alkylation of acrylamides with peroxides to access mono/dialkylated fused N-heterocycles

J. Fan, Q. Yan, X. Wang, L. Li and Z. Li, Org. Biomol. Chem., 2024, 22, 9184 DOI: 10.1039/D4OB01555J

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