Synthesis and structural confirmation of selaginpulvilin X

Abstract

We report the first total synthesis of the natural product selaginpulvilin X, a selaginellaceae polyphenol class of compounds. Our synthetic strategy employs cross-coupling reactions and an organolithium addition to construct the carbon framework. Subsequently, the functional group modifications and deprotection yield the natural product. Spectral analysis confirms the proposed structure by comparing natural and synthetic samples.

Graphical abstract: Synthesis and structural confirmation of selaginpulvilin X

Supplementary files

Article information

Article type
Communication
Submitted
18 Sep 2024
Accepted
01 Oct 2024
First published
02 Oct 2024
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2024, Advance Article

Synthesis and structural confirmation of selaginpulvilin X

T. Havlíková, S. Nallappan, I. Císařová and L. Rycek, Org. Biomol. Chem., 2024, Advance Article , DOI: 10.1039/D4OB01529K

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