Synthetic versatility: the C–P bond odyssey

Abstract

C–P bond formation reactions have garnered significant attention due to the widespread presence of organophosphorus compounds in pharmaceuticals, phosphine-containing ligands, pesticides, and materials science. Consequently, various efficient methodologies have been established in recent decades for constructing C–P bonds. This review article traces the historical evolution of C–P bond research and explores the prospects of C–P bond formation. It contrasts biotechnological approaches with chemical synthesis, emphasizing the critical importance of precision and innovation in developing novel C–P structures. A forward-looking perspective is provided on the role of computational tools and machine learning in optimizing C–P bond synthesis and discovering new compounds. The article explores prospective avenues for reactions that form C–P bonds and advocates for enhanced interdisciplinary collaboration to propel scientific and technological advancements.