Issue 38, 2024

Photochemistry of 2-(2-formylphenyloxy)acetic acid derivatives: synthesis of hydroxychromanones and benzofuranones

Abstract

Photochemical transformations of small molecules, such as ortho-substituted benzaldehydes, in the absence of a photocatalyst are significantly underexplored and may reveal unexpected outcomes. In the present paper, we showed that 2-(2-formylphenoxy)acetic acid and its esters undergo photocyclization into chromanone and benzofuranone derivatives under 365 nm irradiation. The reaction occurs exclusively in dimethyl sulfoxide and can be used to efficiently obtain hydroxychromanones in good yields (27–91%). A detailed mechanistic study revealed the clue of the divergent phototransformation with various products.

Graphical abstract: Photochemistry of 2-(2-formylphenyloxy)acetic acid derivatives: synthesis of hydroxychromanones and benzofuranones

Supplementary files

Article information

Article type
Paper
Submitted
19 Jul 2024
Accepted
29 Aug 2024
First published
29 Aug 2024

Org. Biomol. Chem., 2024,22, 7848-7853

Photochemistry of 2-(2-formylphenyloxy)acetic acid derivatives: synthesis of hydroxychromanones and benzofuranones

E. A. Zhigileva, V. E. Opryshko, A. V. Eshtukov-Shcheglov, D. S. Ivanov, D. I. Rudik, A. A. Mikhaylov, I. A. Ivanov, A. Yu. Smirnov and M. S. Baranov, Org. Biomol. Chem., 2024, 22, 7848 DOI: 10.1039/D4OB01194E

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