Issue 34, 2024

NHC catalyzed radical tandem cyclization: an efficient synthesis of α,α-difluoro-γ-lactam derivatives

Abstract

Herein, an N-heterocyclic carbene (NHC) catalyzed radical tandem cyclization reaction of N-allylbromodifluoroacetamides and aldehydes has been developed. This method is an efficient protocol for synthesizing α,α-difluoro-γ-lactam derivatives in moderate to good yields (27 examples, up to 88% yield and 10 : 1 dr). This strategy features mild and metal-free conditions, high efficiency, and a broad substrate scope.

Graphical abstract: NHC catalyzed radical tandem cyclization: an efficient synthesis of α,α-difluoro-γ-lactam derivatives

Supplementary files

Article information

Article type
Paper
Submitted
17 Jun 2024
Accepted
01 Aug 2024
First published
02 Aug 2024

Org. Biomol. Chem., 2024,22, 6988-6998

NHC catalyzed radical tandem cyclization: an efficient synthesis of α,α-difluoro-γ-lactam derivatives

T. Huang, H. Yin, T. Li, C. Yu, K. Zhang and C. Yao, Org. Biomol. Chem., 2024, 22, 6988 DOI: 10.1039/D4OB01012D

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