In(OTf)3-catalyzed formal (4 + 3) cycloaddition reactions of 3-benzylideneindoline-2-thiones with 2-indolylmethanols

Abstract

We report the In(OTf)₃-catalyzed formal (4 + 3) cycloaddition of 3-benzylideneindoline-2-thiones with 2-indolylmethanols. This reaction not only broadens the synthetic utility of 3-benzylideneindoline-2-thiones as scarce indole-based sulfur-containing four-atom building blocks, but also provides a rapid and facile access to synthesize diindole-annulated tetrahydrothiepines.