Issue 29, 2024

Electrochemical oxidative thioetherification of aldehyde hydrazones with thiophenols

Abstract

An electrochemically promoted oxidative dehydrogenation cross-coupling reaction between aldehyde hydrazones and thiophenols is demonstrated for the first time, which resulted in a variety of (Z)-thioetherified products in moderate to excellent yields. This strategy can be carried out under an air atmosphere, featuring scalability and excellent stereoselectivity. In addition, the transformation efficiently produces readily recyclable disulfide as a by-product with high yields, which significantly reduces the environmental pollution caused by thioetherification.

Graphical abstract: Electrochemical oxidative thioetherification of aldehyde hydrazones with thiophenols

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2024
Accepted
02 Jul 2024
First published
03 Jul 2024

Org. Biomol. Chem., 2024,22, 5907-5912

Electrochemical oxidative thioetherification of aldehyde hydrazones with thiophenols

M. Hu, X. Yang, S. Zhang, C. Qin, Z. Zhang, J. Wang, F. Ji and G. Jiang, Org. Biomol. Chem., 2024, 22, 5907 DOI: 10.1039/D4OB00833B

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