N-Heterocyclic carbene/palladium synergistic catalysis in organic synthesis

Abstract

The cooperation of two distinct catalytic cycles to activate different reactive centers leading to a chemical transformation has been classified as synergistic catalysis. The synergistic combination of NHC with palladium catalysis has emerged as a powerful strategy in the last few years. Merging the ability of NHCs to inverse the polarity of a functional group with the unique reactivity of palladium enables transformations that cannot be accomplished by either of these catalysts alone. Despite the associated challenges, such as quenching of catalysts, reactivity mismatch etc., significant development has been achieved in the field of NHC/Pd synergistic catalysis. The recent incorporation of photoredox catalysis with NHC/Pd synergistic catalysis has further advanced this area. This review highlights the developments made in the area of NHC/Pd synergistic catalysis.