Feijing Chen, Xiao-Xiao Zhao, Hao-Tian Zhang, Yan-Na Ma and Xuenian Chen
Org. Biomol. Chem., 2024,22, 2187-2191
DOI:
10.1039/D4OB00162A,
Communication
The Friedel–Crafts alkylation of arenes is an important part of electrophilic aromatic substitution reactions. However, the reactivity of arenes is weakened by electron-withdrawing substituents, leading to limited substrate scopes and applications. Herein, we developed an efficient HOTf-promoted Friedel–Crafts alkylation reaction of broad arenes with α-aryl-α-diazoesters under metal-free and solvent-free conditions.