Issue 9, 2024

5-exo-Selective asymmetric bromolactonization of stilbenecarboxylic acids catalyzed by phenol-bearing chiral thiourea

Abstract

We developed a novel thiourea Lewis-base catalyst with phenol moieties for the enantioselective 5-exo-bromolactonization of stilbenecarboxylic acids to afford chiral 3-substituted phthalides. The phenol moieties are crucial for the enantio- and regio-selectivity.

Graphical abstract: 5-exo-Selective asymmetric bromolactonization of stilbenecarboxylic acids catalyzed by phenol-bearing chiral thiourea

Supplementary files

Article information

Article type
Communication
Submitted
21 Nov 2023
Accepted
07 Dec 2023
First published
09 Dec 2023

Org. Biomol. Chem., 2024,22, 1765-1769

5-exo-Selective asymmetric bromolactonization of stilbenecarboxylic acids catalyzed by phenol-bearing chiral thiourea

M. Sugano, T. Inokuma, Y. Yamaoka and K. Yamada, Org. Biomol. Chem., 2024, 22, 1765 DOI: 10.1039/D3OB01895D

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