Issue 1, 2024

Sterically demanding Csp2(ortho-substitution)–Csp3(tertiary) bond formation via carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free conditions

Abstract

Construction of the sterically demanding Csp2(oS)–Csp3(T) bond was achieved by carrying out the Pd-catalyzed carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free aqueous conditions. The cooperative role of the presence of water with the absence of phosphine ligand was proposed to accelerate the migratory insertion process considerably, delivering a broad substrate scope.

Graphical abstract: Sterically demanding Csp2(ortho-substitution)–Csp3(tertiary) bond formation via carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free conditions

Supplementary files

Article information

Article type
Communication
Submitted
31 Oct 2023
Accepted
22 Nov 2023
First published
22 Nov 2023
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2024,22, 80-84

Sterically demanding Csp2(ortho-substitution)–Csp3(tertiary) bond formation via carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free conditions

W. Zeng, A. Chen, M. Yan and J. Wang, Org. Biomol. Chem., 2024, 22, 80 DOI: 10.1039/D3OB01784B

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