Issue 7, 2024

Gold-catalyzed cyclization and cycloaddition in natural product synthesis

Abstract

Covering: 2016 to mid 2023

Transition metal catalysis, known for its remarkable capacity to expedite the assembly of molecular complexity from readily available starting materials in a single operation, occupies a central position in contemporary chemical synthesis. Within this landscape, gold-catalyzed reactions present a novel and versatile paradigm, offering robust frameworks for accessing diverse structural motifs. In this review, we highlighted a curated selection of publications in the past 8 years, focusing on the deployment of homogeneous gold catalysis in the ring-forming step for the total synthesis of natural products. These investigations are categorized based on the specific ring formations they engender, accentuating the prevailing gold-catalyzed methodologies applied to surmount intricate challenges in natural products synthesis.

Graphical abstract: Gold-catalyzed cyclization and cycloaddition in natural product synthesis

Article information

Article type
Review Article
Submitted
23 Oct 2023
First published
08 Mar 2024

Nat. Prod. Rep., 2024,41, 1091-1112

Gold-catalyzed cyclization and cycloaddition in natural product synthesis

B. Lin, T. Liu and T. Luo, Nat. Prod. Rep., 2024, 41, 1091 DOI: 10.1039/D3NP00056G

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