Issue 44, 2024

A novel photoelectrochemical aptasensor for alpha-fetoprotein assay based on a 3D self-supporting TiO2/CdS/BiOI Z-scheme heterojunction

Abstract

Alpha-fetoprotein (AFP) is a characteristic marker of liver cancer, and its accurate detection is of great significance for the early detection of liver cancer. This study utilizes visible light as the excitation light source, employs electrochemical measurement, and incorporates the AFP aptamer as the biorecognition element to construct a photoelectrochemical (PEC) biosensor for the highly sensitive detection of AFP. A Z-scheme heterostructure is constructed via a two-step hydrothermal method, and CdS nanoparticles are anchored on TiO2NRA and BiOI nanosheets with high specific surface areas. The photocurrent response of the BiOI/CdS/TiO2NRA composite material is 4.5 times that of TiO2NRA. By analyzing the energy band positions, the electron transfer mechanisms of Z-scheme heterojunctions in CdS/TiO2NRA and BiOI/CdS photoactive materials were elucidated. Subsequently, the AFP aptamer was immobilized on the base electrode surface via the C[double bond, length as m-dash]N structure to fabricate a self-supporting sensing platform. The PEC biosensor demonstrates excellent detection performance within the linear range of 1 nM ∼ 250 nM, exhibiting high selectivity and the detection limit is 0.59 nM (S/N = 3). It has been effectively utilized for the detection of AFP in blood, providing a practical method for early detection and prevention of liver cancer, and also offering new insights for the design of other similar characteristic marker biosensors.

Graphical abstract: A novel photoelectrochemical aptasensor for alpha-fetoprotein assay based on a 3D self-supporting TiO2/CdS/BiOI Z-scheme heterojunction

Article information

Article type
Paper
Submitted
27 Aug 2024
Accepted
15 Oct 2024
First published
28 Oct 2024

New J. Chem., 2024,48, 18873-18882

A novel photoelectrochemical aptasensor for alpha-fetoprotein assay based on a 3D self-supporting TiO2/CdS/BiOI Z-scheme heterojunction

J. Li, T. Jing, H. Qi, Y. Zhao, Y. Wang and L. Fan, New J. Chem., 2024, 48, 18873 DOI: 10.1039/D4NJ03779K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements