CeO2/conjugated polymer heterostructures for dual-modal phototherapy with antibacterial applications

Abstract

This study investigated the synthesis and application of cerium oxide/conjugated polymer (CeO₂/CP) heterostructures for dual-modal phototherapy with a focus on antibacterial applications. CeO₂ nanoparticles were synthesized via a precipitation method and combined with a conjugated polymer, polythiophene, in a 40/60 wt% ratio to form a composite that leveraged the photothermal properties of CeO₂ and the photodynamic capabilities of the polymer. The composite was analyzed with Transmission Electron Microscopy (TEM), X-ray diffraction (XRD), and UV-visible spectroscopy. Its photothermal efficiency and reactive oxygen species (ROS) generation were assessed under near-infrared (NIR) irradiation. Antibacterial tests against E. coli and MRSA demonstrated significant growth inhibition, particularly under elevated temperatures and repeated NIR irradiation cycles. The findings suggested that the CeO₂/CP composite provided enhanced photothermal and photodynamic therapy, showing potential for effective use in medical applications aimed at infection control and enhanced tissue repair.